A Research Team Finds A New Way For Attacking Fatal Brain Cancer
Recently, an international panel of scientists directed by the University of Iowa, Yale University, and the TGen (Translational Genomics Research Institute), has found out a new pathway that might advance success against a deadly type of children’s brain cancer. The research was published in the journal Nature Communications and indicated that scientists have identified an unusual way to disrupting the cellular process that adds to DIPG (diffuse intrinsic pontine gliomas). Reportedly, DIPG is an exceedingly aggressive and fatal type of tumor that develops in the brain stem. This cancer often hits children below 10 Years age, and most of the kids do not survive over a year following diagnosis.
Previously, studies found a genetic mutation known as PPM1D—which is important for cell stress response and cell growth—as a contributor to DIPG. The past attempts to openly attack the PPM1D mutation and proved pointless in managing DIPG. The research team discovered a weakness in the metabolic process for the formation of the NAD, which is a metabolite that is vital for all cell life. Michael Berens—Deputy Director of TGen—said, “This is truly an innovative way of attacking this cancer. We discovered that the mutated gene PPM1D basically sets the foundation for its own termination.”
On a related note, recently, a study stated that an aggressive brain tumor can be identified with a simple blood test in the future. A new study by scientists from the University of Sussex can be the first step toward advancing a blood test to spot the most aggressive kind of brain tumor called glioblastoma. A research team at Professor Georgios Giamas’ laboratory has identified new biomarkers in bodily fluids that indicate the presence of the tumor. The cancer biomarkers are the molecules that are exclusively detected or over-expressed in cancer cells, in comparison to normal or healthy cells. For disease, the biomarkers can be taken into consideration as biological signatures, since they signal the incidence of cancer in the body.